The study examined data from 136,293 study participants, aged 50 to 79, who were not taking antidepressants when they enrolled in the study, and who were followed for an average of six years. The researchers observed a significant difference in stroke rates: antidepressant users were 45 percent more likely to experience strokes than women who weren’t taking antidepressants. The study also found that when overall death rates (all-cause mortality) were compared between the two groups, those on antidepressants had a 32 percent higher risk of death from all causes compared with non-users.