Posts Tagged ‘venlafaxine’

Study shows antidepressants cause major increase in miscarriages (68%) yet pregnant women still being targeted for usage

Thursday, June 24th, 2010

Before It’s News
June 23, 2010

This study comes on the heels of ones showing these drugs cause birth defects. But even now, regulatory agencies aren’t taking action.

Medical powers-that-be are pressing to identify women “at risk” of depression during pregnancy—likely to push them into taking anti-depressants. Now, a study has shown that SSRI and SNRI antidepressants can increase miscarriages by 68 percent. These drugs have also been associated with birth defects. Now, that is truly depressing.

A study published in the online edition of the Canadian Medical Association Journal reported a 68% increase in miscarriages in women who take modern antidepressants. Paroxetine, the SSRI sold as Paxil or Seroxat, and venlafaxine, the SNRI sold as Effexor, were especially risky, and taking more than one antidepressant was also particularly dangerous.

As previously documented in Babies of Women Taking Antidepressants Born With Deformities, Dr. Anick Bérard, PhD, one of the study’s authors, has also noted that antidepressants have been associated with birth defects. It shouldn’t, of course, come as any surprise that an agent guilty of causing birth defects would also result in miscarriages.

Overall, antidepressant use was found to increase the risk of miscarriage by 68%. Paroxetine increased the risk by 75% and venlafaxine more than doubled the risk to a 110% greater chance of spontaneous abortion.

In comparison, the increased risk of miscarriage due to untreated depression is 19 percent.

It’s obvious that increased miscarriage risks of 68 percent, 75 percent, and 110% with SSRI and SNRI treatment make a 19 percent increase in untreated pregnancy depression pale by comparison.

Read entire article: http://beforeitsnews.com/news/84/868/Antidepressants_Cause_Major_Increase_in_Miscarriages.html

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Lawyers & Settlements—Mom Alert: Would you want a 68% Higher Risk of Miscarriage? (Antidepressants & Pregnancy study)

Thursday, June 3rd, 2010

Lawyers & Settlements
By LucyC
June 2, 2010

A new study out yesterday—June 1, 2010—has revealed a higher rate of miscarriages in women who were taking antidepressants during pregnancy. How much higher? Sixty-eight percent—yes —that’s 68%—higher. Frankly, that is nothing short of shocking.

Published in the Canadian Medical Association Journal, the study was done in Canada through the University of Montreal. FYI—This was no small study either—the investigators used data from 5,124 women who are part of a large, population-based study of pregnant women who had clinically verified miscarriages, and a large sample of women from the same registry who did not have a miscarriage. Among the women who miscarried, 284 or 5.5 percent, had taken antidepressants during their pregnancy.

In fact the findings are so robust that the physicians who did the study are suggesting that this is a class effect—in other words the effect could be attributed to all selective serotonin reuptake inhibitors—or SSRIs. Here’s what’s being reported in the press:

“These results, which suggest an overall class effect of selective serotonin reuptake inhibitors, are highly robust given the large number of users studied,” the study’s senior author, Dr. Anick Berard, said in a statement. (UPI.com)

The antidepressants that showed a particular association with miscarriage in the study were paroxetine (trade names: Seroxat and Paxil) and venlafaxine (trade names: Effexor, Efexor, Alventa, Argofan, Trevilor). The investigators also found that the risk of miscarriage doubled with a combination of different antidepressants.

Just for the record, the antidepressants “investigated” in the University of Montreal study are serotonin reuptake inhibitors (citalopram, fluoxetine, fluvoxa-mine, paroxetine and sertraline); tricyclic antidepressants (ami-triptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline, trimipramine), serotonin– norepinephrine reuptake inhibitors (venlafaxine) and “other antidepressants” (serotonin modulators, monoamine oxidase inhibitors, tetracyclic piperazino-azepines, and dopamine and norepinephrine reuptake inhibitors).

This study is just the latest to show an association between, well, for lack of a better term let’s say “serious adverse events” and SSRIs and SNRIs in particular.

Read entire article:  http://www.lawyersandsettlements.com/blog/mom-alert-would-you-want-a-68-higher-risk-of-miscarriage-03819.html

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New Study—Taking Antidepressants While Pregnant More Than Doubles Risk of Miscarriage

Tuesday, June 1st, 2010

Los Angeles Times
By Thomas H. Maugh II
May 31, 2010

Taking antidepressants during pregnancy increases the risk of spontaneous abortions by about two-thirds, Canadian researchers reported Monday. The increased risk was greatest with the family of drugs known as selective serotonin reuptake inhibitors (SSRIs), especially paroxetine and venlafaxine, and when more than one family of drugs were used.

Depression in women is most common during the child-bearing years, and estimates suggest that as many as 15% of pregnant women suffer from it. Because of fears about the effects of drugs, particularly psychiatric drugs, during pregnancy, only about 3.7% of women use them during the first trimester. Most studies looking at the use of antidepressants during pregnancy have focused on their effects on the fetus. Small studies of their effects on abortion have produced inconsistent results. Expecting mothers cannot routinely stop using the drugs, however, because that also presents risks to both the mother and the fetus.

Producing a controlled clinical trial examining the effects of the drugs is virtually impossible because few women would be willing to participate, experts said. The only way to get at the data is to examine it retrospectively.

In the new study, Dr. Anick Berard, director of the University of Montreal’s Research Unit on Medications and Pregnancy at University Hospital Center Sainte-Justine used information from the Quebec Pregnancy Registry to identify 5,124 women who had a spontaneous abortions between 1998 and 2003 — before warnings about the risks of the drugs became more common — and compared them with about 10 times that many carefully matched women who did not have abortions. A separate database provided information about prescriptions the women had filled.

Read entire article:  http://latimesblogs.latimes.com/booster_shots/2010/05/antidepressants-during-pregnancy-increase-risk-of-sponaneous-abortion-study-finds.html

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