Tag Archives: Chantix

PEOPLE’S PHARMACY:Can drugs cause violent behavior?

Americans revere personal responsibility. It resonates with our respect for accountability and frontier justice. That may explain why we have a hard time believing that medications could alter people’s personalities or lead them to behave badly. Violence as a drug side effect seems preposterous to patients, pharmacists, physicians and even juries. Trying to use the “Prozac defense” to justify killing or hurting someone is often met with scorn..

Antidepressant prescribing information, for example, warns physicians that, “All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior.” Drugs such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), paroxetine (Paxil) and sertraline (Zoloft) carry warnings about aggressiveness, agitation, hostility, impulsivity and irritability.

The stop-smoking medication varenicline (Chantix) also comes with warnings about agitation, hostility, depressed mood and changes in behavior. The trouble with such warnings is that people don’t imagine that these bad things could happen to them.

New Study Links ADHD Drugs, Antidepressants, Hypnotics & Anti-Smoking Drug to 1,527 Acts of Violence

For years, there were contentious debates about links between certain prescription meds, notably antidepressants, and suicidal behavior. Now, the focus is turning to violent behavior directed toward others. And a new study is linking 31 widely prescribed drugs – most notably, the Chantix anti-smoking pill – with 1,527 serious acts of violence, such as physical abuse, physical assault and homicide. The study, which was published in PLoS One, identified 484 drugs that accounted for 780,169 serious adverse event reports of all kinds, including 1,937 cases meeting the violence criteria determined by the researchers. There were 387 reports of homicide, 404 physical assaults, 27 cases indicating physical abuse, 896 homicidal ideation reports and 223 cases described as violence-related symptoms.

Besides Pfizer’s Chantix, 11 antidepressants, three ADHD meds and five hypnotics or sedatives were linked to 79 percent of the violence cases. Looked at another way, no cases of violence were reported for 324 of the 484 drugs evaluated. And so an association with violence appeared “highly unlikely” for nearly 85 percent of all evaluated drugs in widespread clinical use.

US Soldiers’ Suicides Caused by Prescription Drugs?

Over 4,000 published reports of violent and bizarre behavior of people affected by antidepressants on the Web archive ssristories.com reveal the same out-of-character violence and self-harm in civilians that is currently seen in the military. Twenty people set themselves on fire. Ten bit their victims (including a biter who was sleepwalking and a woman, on Prozac, who bit her 87-year-old mother into a critical condition.) Three men in the 70s and 80s attacked their wives with hammers. Many stabbed their victims obsessively—one even stabbed furniture after killing his wife—and 14 parents drowned their children, a crime seldom heard of before the 2001 Andrea Yates case. Yates, who drowned her five children, was on the antidepressant Effexor, which manufacturer Wyeth (now Pfizer) “issued no public warning” about [the possibility of violent behavior], says the Associated Press.

Chantix & Violence: What Patients Have In Common

For the past three years, the Chantix smoking cessation pill has caused a stir after being associated with suicidal behavior and vivid dreams. Consequently, the government banned the Pfizer drug for pilots and licenses wouldn’t be issued to truck drivers taking the med. The FDA subsequently imposed a risk management program and Pfizer added warnings.