Posts Tagged ‘Antidepressant’

Manufacturing Depression: The secret history of science run amok, a lust for money & the manufacturing of a disease

Thursday, February 4th, 2010

The Brooklyn Rail
By Kaitlin Bell
February 2010

Gary Greenberg opens his new history of depression with a riveting tale of scientific ingenuity. A young, unknown marine biologist with an interest in mussels happens to discover the neurotransmitter serotonin and helps spur the antidepressant revolution. Lest we get too excited, though, Greenberg deflates our hopes just a few pages in.  Great science stories involve chance discoveries that change our everyday lives, he says—but this is not the kind of story he is going to tell.

Instead, the story that dominates Manufacturing Depression: The Secret History of a Disease is of scientific exuberance run amok, of coincidences and hasty conclusions, of a lust for money and for control over what Greenberg aptly describes as the landscape of mental suffering. Greenberg is outraged that “the depression doctors,” as he ominously terms them, have cornered the market on Americans’ internal anguish and have managed to convince millions of people that their unhappiness is actually a disease with a simple cause—a chemical imbalance—and a magic-bullet cure. It’s especially infuriating because this notion isn’t based in fact; it’s just a story we have allowed the medical establishment to tell us. There is no biochemical marker for depression, no good way to tell who is and who isn’t depressed. The tools doctors use to diagnose depression, as well as the other varieties of mental illness, are based on symptoms alone—whether someone is eating or sleeping more or less than usual, for example, or suffering from excessive guilt, or engaging in too much self-criticism.  Most of what’s diagnosed as depression is, in other words, nothing more than the name our society gives to a particular kind of emotional and mental suffering considered worthy of fixing.

In one sense, Greenberg has reclaimed the narrative very effectively. He has produced a tightly woven history showing that the medical establishment, despite claims to the contrary, knows almost nothing about the causes of depression from a scientific, biochemical, or neurological perspective.

Read entire article:  http://www.brooklynrail.org/2010/02/express/a-frustrating-mess

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Antidepressant no more effective than sugar pills in treating depression

Tuesday, January 5th, 2010

Andrew Stern
Reuters
January 5, 2010

Mild to severe depression might be better treated with alternatives to antidepressant drugs, which do not help patients much more than an inactive placebo, researchers said Tuesday.

Combining data from six studies that examined the effectiveness of two commonly prescribed antidepressants — paroxetine and imipramine — found the drugs produced benefits only slightly greater than a placebo in patients with mild to severe depression.

“They would have done just as well or just about as well with a placebo,” said Robert DeRubeis, a psychologist at the University of Pennsylvania, Philadelphia, who with colleagues performed the meta-analysis.

Paroxetine is one of a popular class of drugs, selective serotonin reuptake inhibitors, and is sold under the brand name Paxil by GlaxoSmithKline. Imipramine is an older tricyclic antidepressant drug developed in the 1950s.

The so-called placebo effect is powerful in treating depression, where people believe they are h

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Before you take that antidepressant, visit website feauturing 3,500 crimes/suicides related to antidepressant use

Monday, January 4th, 2010

Martha Rosenberg
OpEdNews.com
January 3, 2010

With our national love of drugs, sex, celebrities and violence you’d think SSRIstories.com would be more popular.

The 12-year-old web site lists 3,500 crime related news reports linked to the use of SSRI antidepressants with celebrities like Wynona Ryder, Heath Ledger, Brittany Murphy, Anna Nicole Smith, Heather Locklear, Glen Campbell, Carrie Fisher, Sharon Osbourne, Phil Hartman, Princess Di’s driver, Patrick Swayze’s Sister, O.J. Simpson and the Crown Prince of Nepal generously sprinkled in.

You can search and sort stories by drug–Lexapro, Celexa, Luvox, Prozac, Zoloft and Paxil and the related Effexor and Cymbalta–date, location, type of violence and the articles about school shootings, famous cases and legal cases won on SSRI defenses are color coded.

You don’t even have to read the whole article.

SSRIstories founder and manager Betty Henderson pulls out and boldfaces the story’s drug-related citation like Lynyrd Skynyrd harmonicist Mike Caruso’s remark that, “the doctor put me on Cymbalta. That turned me manic,” and Oklahoma murder suspect Ronson Bush’s remark, “I killed my friend when I took these. I’m not going to take them,” when offered SSRIs at the Grady County Jail.

Read entire article: http://www.opednews.com/articles/Before-You-Take-That-Antid-by-Martha-Rosenberg-100103-313.html

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Paxil birth defect settlement tops list of “most impactful” lawsuit settlements for 2009

Tuesday, December 15th, 2009

Kristine B.
LawyersandSettlements.com
December 15, 2009

We’re in the countdown to year-end and looking over some of the more impactful settlements LawyersAndSettlements.com has covered over the past year. When we’re talking impactful, everyone around here has an opinion—so we had to throw in some criteria. To get the nod for impact, a settlement had to be one of two things: 1. High dollar value; or 2. Precedent-setting—or at least have the potential to influence similar cases to follow. (Sounds simple, but you try getting Stephen, John, Jaime, Michelle and Ben to settle in on just 7 settlements with just those criteria…) So here we go…7 game-changing settlements for ‘09…

1) Family takes on GlaxoSmithKline

Michelle David filed a lawsuit against GlaxoSmithKline, alleging the company’s antidepressant, Paxil was responsible for her son’s birth defects. David said she had taken Paxil while pregnant and was not aware of the potential side effects. GlaxoSmithKline said that birth defects occur in between three and five percent of all live births, regardless of Paxil use.

Read entire article: http://www.lawyersandsettlements.com/blog/7-game-changing-settlements-of-2009-02165.html

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Glaxo Said to Have Paid $1 Billion in Paxil Suits Including About $390 Million for Suicides/Attempted Suicides Linked to Drug

Monday, December 14th, 2009

Jef Feeley and Margaret Cronin Fisk
Bloomberg.com
December 14, 2009

GlaxoSmithKline Plc has paid almost $1 billion to resolve lawsuits over Paxil since it introduced the antidepressant in 1993, including about $390 million for suicides or attempted suicides said to be linked to the drug, according to court records and people familiar with the cases.

As part of the total, Glaxo, the U.K.’s largest drugmaker, so far has paid $200 million to settle Paxil addiction and birth-defect cases and $400 million to end antitrust, fraud and design claims, according to the people and court records.

The $1 billion “would be worse than many people are expecting,” said Navid Malik, an analyst at Matrix Corporate Capital in London. “I don’t think this is within the boundaries of current assumptions for analysts.”

The London-based company hasn’t disclosed the settlement total in company filings. It has made public some accords. Glaxo’s provision for legal and other non-tax disputes as of the end of 2008 was 1.9 billion pounds ($3.09 billion), according to its latest annual report. This included all legal matters, not just Paxil. The company said 112 million pounds of this sum would be “reimbursed by third-party issuers.”

Read entire article: http://www.bloomberg.com/apps/news?pid=20601103&sid=aWNKB4YPWjIY

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US Kids Represent Psychiatric Drug Goldmine

Monday, December 14th, 2009

Truthout
Evelyn Pringle
December 12, 2009

Prescriptions for psychiatric drugs increased 50 percent with children in the US, and 73 percent among adults, from 1996 to 2006, according to a study in the May/June 2009 issue of the journal Health Affairs. Another study in the same issue of Health Affairs found spending for mental health care grew more than 30 percent over the same ten-year period, with almost all of the increase due to psychiatric drug costs.

On April 22, 2009, the US Agency for Healthcare Research and Quality reported that in 2006 more money was spent on treating mental disorders in children aged 0 to 17 than for any other medical condition, with a total of $8.9 billion. By comparison, the cost of treating trauma-related disorders, including fractures, sprains, burns, and other physical injuries, was only $6.1 billion.

In 2008, psychiatric drug makers had overall sales in the US of $14.6 billion from antipsychotics, $9.6 billion off antidepressants, $11.3 billion from antiseizure drugs and $4.8 billion in sales of ADHD drugs, for a grand total of $40.3 billion.

The path to child drugging in the US started with providing adolescents with stimulants for ADHD in the early 80s. That was followed by Prozac in the late 80s, and in the mid-90s drug companies started claiming that ADHD kids really had bipolar disorder, coinciding with the marketing of epilepsy drugs as “mood stablizers” and the arrival of the new atypical antipsychotics.

Read entire article: http://www.truthout.org/1213091

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Father sues Harvard over son’s suicide – 3 psychiatric drugs prescribed him were all documented to cause suicide

Saturday, December 5th, 2009

Thom Weidlich
Bloomberg.com
December 5, 2009

The father of a Harvard College sophomore who killed himself in 2007 sued the school’s president and fellows for wrongful death, alleging the institution’s health service prescribed drugs known to increase suicide risk.

John B. Edwards II of Wellesley, Massachusetts, sued on behalf of the estate of his son, known as Johnny, in state court in Middlesex County on Dec. 2. A doctor and nurse employed by Harvard simultaneously prescribed skin, antidepressant and attention-deficit disorder drugs linked to suicide and other side effects, according to the complaint.

“Three of these drugs have risks associated with heightened suicidality,” the father’s lawyer alleged in the complaint. “All four drugs have significant side effects.”

Harvard College in Cambridge, Massachusetts is the undergraduate school of Harvard University, whose $26-billion endowment is the world’s largest academic fund.

“The care he received at Harvard University Health Services was thorough and appropriate and he was monitored closely by its physicians and allied health specialists,” Harvard said yesterday in an e-mailed statement. “Similar complaints previously have been filed with the Board of Registration in Medicine, the Board of Registration in Nursing and the Board of Registration in Pharmacy, and in all three instances the complaints were dismissed upon review.”

Read entire article:  http://www.bloomberg.com/apps/news?pid=20601103&sid=aIlr9YQwCSnY

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Pregnant women should stop medications which cause birth defects: “Psychiatric drugs can & should be avoided”

Monday, November 30th, 2009

The Daily Inquirer
November 29, 2009

Canadian researchers are saying that women who are planning to become pregnant should take an inventory of the medications they take.

The researchers have found that many pregnant women still take medications which can cause birth defects.

Dr. Anick Berard, at the University of Montreal in Quebec, said drugs that control epilepsy are essential during pregnancy, albeit known to have fetal risk.

However, medications such as those which treat severe acne, anxiety and psychiatric drugs, antibiotics, and many drugs prescribed for heart disease and medical conditions “can and should be avoided,” according to Berard.

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Psycho/Pharma invents ‘hypoactive sexual desire disorder’ to sell female ‘Viagra’ (antidepressant)

Wednesday, November 18th, 2009

Zosia Bielski
Globe and Mail
November 18, 2009

A German pharmaceutical company is touting one of its failed antidepressants as a libido-boosting drug for women.

Flibanserin can increase sexual desire in women suffering from “hypoactive sexual desire disorder,” according to three clinical trials funded by the company, Boehringer Ingelheim. The results were presented yesterday at the Congress of the European Society for Sexual Medicine in Lyon, France.

The disorder is a branch of “female sexual dysfunction,” a widely debated term that involves everything from an inability to reach orgasm to a lack of desire.

Described as a “Viagra-like drug for women” by one of the trials’ principal investigators, flibanserin is prompting an outcry from critics who say female sexual dysfunction is a disorder the pharmaceutical industry has conjured as an attempt to capitalize on women’s complex sexuality.

In two North American trials, the company surveyed 1,378 women with hypoactive sexual desire disorder. Another trial was conducted in Europe.

According to the Diagnostic and Statistical Manual of Mental Disorders, a reference guide for the medical profession, the condition is accompanied by a persistent absence of sexual fantasies or desire for any form of sexual activity. The disorder is marked by distress and difficulties in a relationship.

Read entire article: http://www.theglobeandmail.com/life/health/drug-firm-touts-failed-antidepressant-as-viagra-for-women/article1365641/

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Failed antidepressant being repackaged and marketed as Viagra for women…(no joke)

Monday, November 16th, 2009

Dana Blankenhorn
SmartPlanet.com
November 16, 2009

It’s a great example of how drug companies try to turn their lemons into lemonade.

Flibanserin was developed by a German company, Boehringer Ingelheim, originally as an anti-depressant. You may have never heard of Boehringer, but it’s an old name in the drug game, producing such common drugs as Dulcolax, Flomax, Spiriva, and Zantac, among others.

Flibanserin failed its trials as an anti-depressant, but when the company asked test subjects to return the unused portion, patients were reluctant. (The 2001 movie Serendipity starred John Cusack and Kate Beckinsale.)

So, like any good drug maker Boehringer tried, tried again. What the University of North Carolina now reports is that it increases a woman’s sex drive.

A lot of the media is touting this as “female Viagra,” but it’s really no such thing. Viagra makes sex possible. Flibanserin just seems to make it desirable. Boehringer funded the UNC study.

Read entire article: http://www.smartplanet.com/technology/blog/rethinking-healthcare/can-a-bad-anti-depressant-be-a-good-sex-aid/613/

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