Posts Tagged ‘ADRs’

New Dawn Magazine—The Brave New World of Pre-Drugging Kids:Patrick McGorry & Psychosis Risk Syndrome by Jan Eastgate

Thursday, July 8th, 2010

New Dawn
By Jan Eastgate
July 8, 2010

Imagine being a parent taking your 10-year-old daughter to the doctor where she gasps for air and suddenly dies in your arms. You are informed afterwards that a toxic dose of prescribed medication caused her death.

Imagine leaving your house to have lunch with friends, while your husband and 11-year-old daughter are happily cuddled together watching your daughter’s favourite TV show Animal Planet. You return home hours later, walk upstairs to her bedroom and find her hanging from the valence of her bed.

Imagine your teenage son is prescribed a medicine because a teacher said he needs it to curb his disruptive behaviour. Months later he is diagnosed with severe diabetes – a known but covered up side effect by the makers of the medicine. He dies shortly afterwards from complications.

These are not isolated incidents. They are representative of those thousands of children and adolescents who died while taking prescribed psychotropic (mind-altering) drugs in the United States. In the above cases, the drugs were prescribed to treat anxiety experienced while sitting for exams or for so-called “Attention Deficit Hyperactivity Disorder” (ADHD), the symptoms of which include fidgeting, losing your pencils, not sitting still, running about or excessively climbing, and butting into other’s conversations.

Australian Child Deaths

An estimated 1,900 Australians under the age of 19 have died while on antidepressants and antipsychotics. More than 30,700 under 18-year-olds were prescribed antidepressants in 2007-2008, including 550 aged 5 and under. Side effects include hallucinations, hostility, psychosis and suicide.

During the same period, more than 9,300 children under 18 – some as young as one – were prescribed antipsychotics, costing the government $3.4 million. Of the 477 deaths reported to the Australian Therapeutic Goods Administration (TGA) linked to antipsychotics, 15 were for ages 0 to 19, including intrauterine deaths. Experts estimate only 1 percent of Adverse Drug Reactions (ADRs) are reported to the TGA, so deaths could be as high as 1,500.

Common side effects of antipsychotics include excessive weight gain, life-threatening diabetes, and an irreversible neurological effect called Tardive Dyskinesia that manifests in uncontrollable twitching of the muscles and extremities and tongue movements. Another adverse effect, Neuroleptic malignant syndrome (NMS) can cause sudden death.1 Statistics the Citizens Commission on Human Rights obtained from the TGA in 2009 revealed 14 incidents of 10 to 19 year olds experiencing NMS were reported to it.

The psychiatric drug abuse of young Australians prompted one Western Australian MP recently to call for a national inquiry into the use of psychotropic drugs in children. To date, the federal government has yet to act.

Instead, it has potentially exacerbated the situation, handing over more than one hundred million taxpayer dollars to Patrick McGorry, Professor of Youth Mental Health at the University of Melbourne, Executive Director of ORYGEN Research Centre, and founder of the youth mental health centre chain, headspace.

Read entire article: http://www.newdawnmagazine.com/articles/the-brave-new-world-of-pre-drugging-kids-patrick-mcgorry-psychosis-risk-syndrome

« Return to news items


Share

Medscape – Psychotropic Medications Linked to Serious Adverse Drug Reactions in Children

Friday, July 2nd, 2010

Medscape
By Deborah Brauser
July 2, 2010

Psychotropic medications are associated with adverse drug reactions (ADRs), many of which are serious, in children younger than 17 years, according to a new database study from Danish researchers.

Results also showed that all but one of the psychotropic-related ADRs for children between the ages of birth and 2 years were serious, including birth defects such as neonatal withdrawal syndrome, ventricular septal defects, and premature labor.

These findings were “probably due to the mothers’ intake of psychotropic medicine, primarily antidepressants and antipsychotics, during pregnancy,” write the study authors.

For the overall patient population, the largest share of reported ADRs came from psychostimulants (42%), followed by antidepressants (31%) and antipsychotics (24.5%).

“The high number of serious ADRs reported for psychotropic medicines in the pediatric population should be a concern for health care professionals and physicians,” the study authors write.

In addition, “clinicians must be aware of the risks for the unborn child if they treat pregnant women with [these drugs],” coinvestigator Ebba Hansen, MSc, professor of social pharmacy and director for the FKL-Research Center for Quality in Medicine Use at the University of Copenhagen, Denmark, told Medscape Medical News.

She noted that many of the general practitioners interviewed for this study “thought that SSRI [selective serotonin reuptake inhibitor] antidepressants are harmless. Therefore, we recommend that treatment of pregnant women with psychotropic drugs should be an issue for specialists only.”

The study is published online in BMC Research Notes.

ADR Evidence Lacking

Although regulatory authorities have issued warnings about risks associated with the use of psychotropics in pediatric patients, “little evidence has been reported about the ADRs of these medicines in practice,” write the study authors.

“Overall, we have very little information about [ADRs] in children, and especially in infants, as vulnerable groups are excluded from the clinical trials that document a medication’s efficacy and safety before licensing and marketing,” said Professor Hansen.

For this study, her team evaluated 4500 ADRs in children listed in the national Danish ADR database between 1998 and 2007.

“Spontaneous ADR reporting [is] an important contributor to knowledge about safety of medicines,” the study authors write. They note that spontaneous reports are “the main source for information about new and previous unknown ADRs.”

Serious ADRs Found

Results showed that 429 of the ADRs reported during the study period were for psychotropic medications. Of these, 241 (56%) were deemed serious.

A total of 50% of the psychotropic ADRs reported were for adolescents between the ages of 11 and 17 years (n = 214), of which 45% were serious. Almost 19% were for children between the ages of birth and 2 years (n = 80).

In addition, 39% of the overall psychotropic-related ADRs were from the “nervous and psychiatric disorders” categories. When looking at sex, 59% of the total ADRs reported were for boys.

A total of 79 of the 80 ADRs associated with psychotropics in the children younger than 2 years were serious, and 2 of these were fatal (one was associated with citalopram due to chorioamnionitis and the other with fluoxetine due to persistent fetal circulation).

Finally, 40% of all psychotropic ADRs were associated with the psychostimulants methylphenidate and atomoxetine, whereas 59% of the ADRs reported for antipsychotics were associated with ziprasidone, olanzapine, and risperidone. A total of 61% of the total ADRs reported for antidepressants were with sertraline and citalopram.

Read entire article:  http://www.medscape.com/viewarticle/724547
(Free registration required for Medscape)

« Return to news items


Share