Posts Tagged ‘Abilify’

Prescription Pill-Popping By Far a Leading Killer as Florida’s Drug Deaths Spike 20%

Thursday, July 1st, 2010

FlaglerLive.Com
July 1, 2010

Oxycodone, the addictive prescription pain-killer also known by its Purdue Pharma brand name OxyContin, directly caused more deaths in Florida in 2009 than cocaine, heroin and morphine combined. Prescription drugs as a whole are killing far more Floridians than illegal drugs, with some 8,600 deaths last year involving at least one prescription drug, according to an annual report released today by the Florida Medical Examiners Commission.

That’s 5 percent of all deaths in Florida in 2009, when 171,300 people died in the state.

The number of people killed by prescription drugs is a significant 20 percent increase over last year’s 6,200 deaths attributed to overdoses. Much of the increase is due to a spike in oxycodone addiction. The increase in prescription-drug addiction continues a trend that began in Florida 10 years ago, when prescription drugs overtook illegal drugs as leading causes of drug-related deaths.

Alcohol is also included in the examiners’ analysis, and it leads the way of all drug-related deaths, with 4,046.

The annual report is a stark look at the effects of legalized drug addiction and over-prescription of drugs, both of which affect a far larger segment of the population than recreational or illegal narcotics.

For the first time in 2009, the commission tracked deaths by region. In Flagler County’s district, which includes St. Johns and Putnam counties, 22 deaths were attributed to oxycodone (the fourth lowest number in the state’s 23 districts), with 13 of those deaths directly attributed to the drug, and nine cited as being present among other drugs that contributed to death.

Hydrocodone claimed 16 lives in the district. Cocaine contributed to 19 deaths in the Flagler district, though only four cases were directly attributed to the drug. In 15 cases, cocaine was present in the body in conjunction with other drugs that proved lethal. Overall in Florida, cocaine-related deaths (including the majority of cases where cocaine wasn’t directly the factor but was present in the body at the time of death), have fallen from a peak of 2,179 in 2007 to 1,462 in 2009. (Again, cocaine was the direct result of death in 529 cases out of those).

Ken Kramer, a researcher with the Citizens Commission on Human Rights of Florida, says the numbers underestimate the extent of the problem, because medical examiners do not track deaths attributed to antipsychotic drugs or to antidepressants, both of which carry black-box or black-label warnings. The warnings on antidepressants, required by the Food and Drug Administration, state that the drugs increase the risk of suicidal thinking and behavior in children, adolescents and young adults up to age 24. (Antidepressants include Paxil, Prozac, Zoloft, Effexor, Lexapro and Celexa.)

Anti-psychotic drugs carry a variety of black label warnings of increased mortality in elderly patients (including a death rate almost twice as high for people taking Risperdal, for example). Those drugs, prescribed and often overprescribed in nursing homes and assisted living facilities, include Abilify, Clozaril, Geodon, Risperdal, Seroquel and Zyprexa.

“Certainly, the actual number of prescription drug deaths is higher than the annual report states,” Kramer said. “It is unknown just how much higher because the Medical Examiners Commission does not track these classes of drugs.”

Two years ago Kramer got his concern heard by the commission following an email exchange with a commissioner in which he argued that antidepressants and anti-psychotic drugs’ contributions to mortality should be part of the annual report. He was rebuffed. One examiner vsaid he had not seen “more than the occasional death caused by these types of drugs,” according to the minutes of the Aug. 13, 2008 meeting of the commission.

Read entire article:  http://flaglerlive.com/7256/florida-prescription-drugs-deaths-oxycontin-oxycodone

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Australia’s “growing problem” is child drugging—Antipsychotics given to toddlers linked to 45 child deaths in the U.S.

Tuesday, March 23rd, 2010

The Herald Sun
March 24, 2010

CHILDREN as young as one are being prescribed powerful anti-psychotic drugs that have been linked to deaths overseas.

The strong medication is designed to quell psychotic episodes normally experienced by adults with schizophrenia and bi-polar.

There are concerns some doctors are illegitimately writing scripts for pre-schoolers and primary school children for unapproved medical reasons, such as behavioural problems or ADHD.

Figures provided by the Therapeutic Goods Administration showed up to 3351 NSW children aged under 18 were prescribed the drugs in 2007-08.

Of them, at least 62 toddlers aged five and under — including five one-year-olds — were prescribed the drugs in NSW in that period.

“You can assume children under 12 are illegitimately being prescribed these drugs for behaviour problems. It should not be the case,” University of South Australia’s associate professor in psychiatry Dr Jon Jureidini said yesterday.

“These drugs are not marketed or recommended by the TGA for that use.”

Common medications such as Risperdal, Zyprexa and Abilify are not approved for children under five. The TGA has approved Risperdal to treat children with autism.

Side effects can be so severe in adults that elderly patients with dementia are warned they have a higher risk of sudden death.

Read entire article:  http://www.heraldsun.com.au/news/national/kids-prescribed-toxic-drug-cocktail-of-anti-depressants/story-e6frf7l6-1225844541982

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Australia: Documents reveal 10,000 kids prescribed powerful, dangerous anti-psychotic drugs including toddlers

Tuesday, March 23rd, 2010

The Herald Sun
March 24, 2010

CHILDREN as young as two are being prescribed anti-psychotic drugs that have been linked to deaths overseas.

Almost 2000 children aged under 18 were prescribed the drugs in Victoria in 2007-08.

Figures provided by the Therapeutic Goods Administration reveal at least four two-year-olds were among 422 under-10s given drugs designed to quell psychotic episodes normally found in adults with schizophrenia and bi-polar disorder.

But there are concerns some doctors are writing scripts for preschoolers and primary school children for unapproved medical reasons, such as behavioural problems.

“You can assume children under 12 are illegitimately being prescribed these drugs for behaviour problems. It should not be the case,” said University of South Australia’s Assoc Prof in psychiatry Dr Jon Jureidini.

“The vast majority of preschoolers who are prescribed are not for psychotic episodes but for behaviour problems,” he said.

“These drugs are not marketed, or recommended by the TGA, for that use.”

Common medications such as Risperdal, Zyprexa and Abilify are not approved for use in children under five due to the lack of evidence on their safety.

But the TGA has approved Risperdal to treat children with autism.

In 2007-08, almost 10,000 under-18s were prescribed anti-psychotic medication in Australia.

Side-effects can be so severe in adults that elderly patients with dementia are warned they have a higher risk of sudden death.

Read entire article:  http://www.heraldsun.com.au/news/victoria/toddlers-given-anti-psychotic-drugs/story-e6frf7kx-1225844491890

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Drugging Kids For Profit: Powerful & dangerous antipsychotic drugs being used on kids more and more often

Monday, January 4th, 2010

Ed Silverman
Portfolio.com
January 4, 2010

If elderly people with dementia are so vulnerable to the risks posed by antipsychotics, why are so many nursing-home residents regularly prescribed the medications?

The answer can be found in a controversy with its roots in aggressive marketing and lackadaisical supervision. Known in the medical community as atypical antipsychotics, this group of drugs was originally approved by the Food and Drug Administration to treat adults suffering from schizophrenia. They go by snazzy names such as Zyprexa, Geodon, Abilify, and Seroquel. Later, regulators allowed doctors to prescribe them for treating bipolar disorder. Over the past decade, the pills have become a veritable goldmine; in 2008 alone, sales in the U.S. reached $14.6 billion.

But critics say those big sales are actually due, in part, to an epidemic of off-label marketing, which is promoting a drug for unapproved uses, although doctors are free to write a prescription regardless. And so drugmakers encouraged doctors to prescribe these meds for children before the FDA sanctioned their use for youngsters. This was particularly troubling, given that the drugs can cause diabetes and weight gain, side effects that prompted thousands of lawsuits claiming that drugmakers tried to hide evidence of these problems.

Read entire article: http://www.portfolio.com/industry-news/health-care/2010/01/04/drugging-kids-for-profit/

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FDA ‘considers’ Antipsychotic drug labels warning of weight gain/diabetes. Considers? Do your job-issue the warnings.

Wednesday, December 9th, 2009

Jennifer Corbett Dooren
The Wall Street Journal
December 8, 2009

WASHINGTON (Dow Jones)–A top Food and Drug Administration official said Tuesday the agency is considering strengthening the labels of antipsychotic drugs to warn about weight gain and diabetes amid concerns the impact could be stronger in children compared to adults.

Thomas Laughren, the director of FDA’s division of psychiatric products, said the agency has asked manufacturers of drugs like Seroquel, Abilify and Zyprexa for all of the information they have on metabolic side effects such as increases in blood glucose, which can cause diabetes and blood cholesterol levels which can lead to cardiovascular problems over time.

While the labels of the drugs already discuss weight gain and its associated problems, Laughren said the agency is considering putting all the information in the warnings section, which would amount to a strengthening of the warning.

Laughren made his comments Tuesday at a pediatric advisory committee meeting which was reviewing the safety of several drugs used in children, including antipsychotics.

Laughren said the labels for AstraZeneca PLC’s (AZN) Seroquel and Eli Lilly & Co.’s (LLY) Zyprexa were already changed last week when the agency approved the products for use in younger patients and, in Seroquel’s case, when it was approved as an add-on treatment for major depression. However, he said all of the drug labels in the class could change as the FDA continues its “comprehensive” review.

The drugs are used to treat a variety of mental illnesses, including bipolar disorder, schizophrenia and depression that doesn’t respond to other types of medication.

A study published last month in the Journal of the American Medical Association found the drugs caused children and adolescents to gain an average of 19 pounds in 11 weeks of treatment. The concern with weight gain seen with most antipsychotic drugs is whether it causes additional problems such as diabetes and cardiovascular disease.

In advance of the pediatric panel meeting, FDA staff recommended the agency should conduct an additional review of antipsychotic drugs to look at the impact of weight gain in children. Several studies have shown children and adolescents gain weight at a faster rate than adults.

Other drugs in the class include Risperdal, made by a unit of Johnson & Johnson (JNJ); Abilify, by Bristol-Myers Squibb Co. (BMY) and Otsuka Pharmaceutical Co.; and Pfizer Inc.’s (PFE) Geodon. Antipsychotics were the top-selling drug class in the U.S. last year, with $14.6 billion in sales, ahead of the $14.5 billion in sales of cholesterol drugs, according to IMS Health.

See article: http://online.wsj.com/article/BT-CO-20091208-714877.html

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With 2 million kids on antipsychotics (extremely powerful/dangerous drugs) FDA finally urges review of use in kids

Friday, December 4th, 2009

AttorneyAtLaw.com
December 4, 2009

The use of powerful antipsychotic drugs like Seroquel and Zyprexa in children should be further studied to determine the risks of metabolic disorders and other serious health complications, Food and Drug Administration staffers say in a new report.

FDA drug reviewers said medical researchers have found a direct link between the use of so-called atypical antipsychotics in younger children and weight gain, high cholesterol, and increased blood pressure, according to a Reuters news report.

Seroquel, Zyprexa and similar antipsychotic drugs are not approved for use in children, but an estimated two million American children are given the drugs by doctors each year to treat a variety of psychiatric disorders. An FDA advisory panel recently recommended approving their use in kids.

The research findings should prompt further FDA evaluation to determine the extent of the risks and possibly take action to limit the use of Zyprexa, Seroquel, and similar drugs in younger age groups, staff in the FDA’s division of pharmacovigilance wrote in an October 14 memo, according to Reuters.

Read entire article: http://www.attorneyatlaw.com/2009/12/fda-staff-urges-more-review-of-seroquel-and-zyprexa-use-in-kids/

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Antipsychotics Like Seroquel Blamed for Deaths and Strokes

Monday, November 16th, 2009

AboutLawsuits.com
November 16, 2009

According to a new report, side effects of antipsychotics, such as Seroquel, Zyprexa, Risperdal and Abilify, could be responsible for as many as 1,800 deaths and 1,620 strokes each year among the elderly with dementia in the United Kingdom.

The report, which was commissioned by the British government, found that the use of antipsychotics for dementia has been largely ineffective, resulting in improvement in only 20% of patients. As a result of the findings, the U.K. Department of Health has initiated plans to reduce the use of atypical antipsychotic drugs like Zyprexa, Risperdal, Abilify and Serquel for dementia in its own health system, and hopes that the reduction will be picked up by other nations as well.

There are an estimated 180,000 elderly people with dementia in the United Kingdom currently being treated with the antipsychotic drugs, according to the report’s author, Professor Sube Banerjee. However, only 36,000 were found to derive any benefit from the drugs.

“The findings of my review confirm that there are indeed significant issues in terms of quality of care and patient safety,” said Banerjee, professor of mental health at King’s College London Institute of Psychiatry, in a letter to the Minister of State that accompanied the report. “These drugs appear to be used too often in dementia and, at their likely level of use, potential benefits are most probably outweighed by their risks overall.”

Read entire article: http://www.aboutlawsuits.com/antipsychotics-for-dementia-blamed-for-deaths-6965/

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Dr. Peter Breggin: Antipsychotic Drugs, Their Harmful Effects, and the Limits of Tort Reform

Monday, November 2nd, 2009

Dr. Peter Breggin
The Huffington Post
October 31, 2009

There are many problems within our legal system that could benefit from reform. But within the area in which I have great experience as a psychiatric expert, so-called tort reform has already gone too far. It is already too difficult for injured patients or their surviving families to bring malpractice suits against physicians and health facilities, and product liability suits against drug companies, even when their cases have great merit. I believe in private health care and I believe in the free market, but liberty requires checks and balances. The right to sue medical practitioners and pharmaceutical companies provides a necessary control in our free market system, as well as a means for individuals to seek compensation and justice.

Harm Caused by Antipsychotic Drugs

For illustrative purposes, I’ll focus on the newer antipsychotic drugs, the so-called atypicals, including Zyprexa, Risperdal, Geodon, Seroquel, and Abilify. These drugs produce horrendous adverse effects that often lead the victims or their surviving families to consider bringing lawsuits against doctors, health care facilities, or drug companies.

First, the antipsychotic drugs produce tardive dyskinesia. Tardive dyskinesia involves drug-induced abnormal movements that commonly disfigure patients and in some cases result in lifelong pain and total disability.

Read entire article: http://www.huffingtonpost.com/dr-peter-breggin/antipsychotic-drugs-their_b_341108.html

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Forbes: New study shows “Hefty Side Effect For Kids On Antipsychotics”

Wednesday, October 28th, 2009

Robert Langreth
Forbes
October 27, 2009

A new study is likely to add to the furious debate over the rapid rise in the prescription of heavy-duty antipsychotic drugs to children. It found that kids’ weight balloons by 10 to 19 pounds in just the first three months on the drugs, often leading to worrisome elevations of cholesterol, triglycerides and other metabolic parameters.

Weight gain is a known side effect of the drugs, but the new study is notable because it found far greater increases than had been seen in many previous trials. Researchers tracked 272 children between the ages of 4 and 19 who started taking various brand-name antipsychotic drugs for the first time between 2001 and 2007. They found weight gains varied by drug but appeared to be widespread across the entire class of medications, called atypical antipsychotic drugs.

“Weight gain was pervasive even in medications usually considered to be weight neutral in adults,” says Albert Einstein College of Medicine psychiatrist Christoph Correll, who led the study, which was conducted at the Zucker Hillside Hospital in Queens, N.Y. “The worry is that weight gain sustained over long periods of time can cause adverse outcomes like diabetes and heart attacks and strokes.”

Read entire article: http://www.forbes.com/2009/10/27/antipsychotics-lilly-astrazeneca-business-healthcare-children.html

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