This table shows all Adverse Drug Reactions reported to the FDA's Adverse Event Reporting System between 2004 and the 2nd Quarter of 2008 where the listed psychiatric drug was identified as the Primary Suspect Drug (FDA's term) deemed responsible for causing or inducing these reactions and where one or more of the Adverse Reactions reported for the Case described a congenital, prenatal or neonatal condition. Where no Age, Date of Event or Indication (the condition being treated) are shown, none were present in the FDA records.

Reported By: CN-Consumer, LW-Lawyer, MD-Physician, OT-Other Healthcare Provider, PH-Pharmacist, Blank-Not Reported in ISR (Individual Safety Report).

The Oxford English Dictionary defines a poison as "a substance that causes death or harm when introduced into or absorbed by a living organism."  This psychiatric drug fits that definition.

Daxid (sertraline), Gladem (sertraline), Lustral (sertraline), Serlain (sertraline), Sertraline (sertraline), Tresleen (sertraline), Zoloft (sertraline)

Abdominal Pain, Abdominal Pain Lower, Abdominal Pain Upper, Abnormal Behaviour, Abnormal Labour, Abnormal Palmar/Plantar Creases, Abortion, Abortion Early, Abortion Induced, Abortion Missed, Abortion Spontaneous, Adenocarcinoma, Adenotonsillectomy, Adjustment Disorder, Affective Disorder, Aggression, Agitation, Agitation Neonatal, Agonal Rhythm, Alcoholism, Alpha 1 Foetoprotein Amniotic Fluid Increased, Alpha 1 Foetoprotein Increased, Amenorrhoea, Amnesia, Amniotic Fluid Volume Decreased, Amniotic Fluid Volume Increased, Anaemia, Anal Atresia, Anencephaly, Anger, Angiopathy, Ankyloglossia Congenital, Anomalous Pulmonary Venous Connection, Anomaly of External Ear Congenital, Anorectal Disorder, Ano-Rectal Stenosis, Anorexia, Antepartum Haemorrhage, Antiphospholipid Syndrome, Anxiety, Aortic Disorder, Aortic Elongation, Aortic Stenosis, Aortic Valve Incompetence, Aortic Valve Stenosis, Apgar Score Low, Apnoea, Appendicectomy, Arrested Labour, Arrhythmia Neonatal, Arterial Disorder, Arthritis, Arthropathy, Asplenia, Assisted Fertilisation, Asthma, Atrial Septal Defect, Atrioventricular Septal Defect, Attention Deficit Hyperactivity Disorder, Attention Deficit/Hyperactivity Disorder, Auricular Swelling, Autism, Autism Spectrum Disorder, Autoimmune Thyroiditis, Back Pain, Bacterial Infection, Bed Rest, Benign Hydatidiform Mole, Beta Haemolytic Streptococcal Infection, Bicuspid Aortic Valve, Bipolar Disorder, Bipolar I Disorder, Birth Trauma, Blindness, Blood Bilirubin Increased, Blood Cholesterol Increased, Blood Glucose Abnormal, Blood Glucose Decreased, Blood Human Chorionic Gonadotropin Decreased, Blood Magnesium Decreased, Blood PH Decreased, Blood Pressure Decreased, Blood Pressure Increased, Blood Pressure Systolic Decreased, Blood Prolactin Increased, Body Height Below Normal, Body Temperature Decreased, Body Temperature Increased, Bone Disorder, Bradycardia, Bradycardia Foetal, Bradycardia Neonatal, Brain Damage, Brain Malformation, Breast Pain, Breech Delivery, Breech Presentation, Bronchitis, Bruxism, Burning Sensation, Caesarean Section, Cardiac Arrest, Cardiac Disorder, Cardiac Failure, Cardiac Failure Congestive, Cardiac Murmur, Cardiac Perforation, Cardiac Septal Defect, Cardiac Valve Disease, Cardiomegaly, Cardiomyopathy, Caudal Regression Syndrome, Cephalhaematoma, Cerebellar Hypoplasia, Cerebral Cyst, Cerebral Disorder, Cerebral Haemorrhage, Cerebral Haemorrhage Neonatal, Cerebral Palsy, Cerebral Ventricle Dilatation, Cerebrovascular Accident, Chlamydial Infection, Choking, Cholecystectomy, Chorioamnionitis, Chromosome Abnormality, Circulatory Failure Neonatal, Clavicle Fracture, Cleft Lip, Cleft Lip and Palate, Cleft Palate, Coarctation of the Aorta, Cognitive Disorder, Collapse of Lung, Colonic Obstruction, Coma, Complement Factor C4, Complement Factor C4 Decreased, Completed Suicide, Complications of Maternal Exposure To Therapeutic Drugs, Compression Fracture, Condition Aggravated, Confusional State, Congenital Absence of Bile Ducts, Congenital Absence of Cranial Vault, Congenital Anomaly, Congenital Arterial Malformation, Congenital Brain Damage, Congenital Cardiovascular Anomaly, Congenital Central Nervous System Anomaly, Congenital Diaphragmatic Anomaly, Congenital Diaphragmatic Hernia, Congenital Foot Malformation, Congenital Great Vessel Anomaly, Congenital Hand Malformation, Congenital Heart Valve Disorder, Congenital Macrocephaly, Congenital Neurological Disorder, Congenital Nose Malformation, Congenital Nystagmus, Congenital Oesophageal Web, Congenital Pulmonary Hypertension, Congenital Pulmonary Valve Atresia, Congenital Tricuspid Valve Atresia, Constipation, Contusion, Convulsion, Convulsion Neonatal, Coombs Direct Test Positive, Coombs Test Positive, Craniosynostosis, Croup Infectious, Crying, Cyanosis, Cyanosis Neonatal, Dacryostenosis Congenital, Deafness, Death, Death Neonatal, Decreased Appetite, Deformity, Dehydration, Dental Caries, Depersonalisation, Depressed Mood, Depression, Developmental Coordination Disorder, Developmental Delay, Dextrocardia, Diabetes Insipidus, Diarrhoea, DiGeorge's Syndrome, Discomfort, Disease Recurrence, Disorientation, Disturbance In Attention, Divorced, Dizziness, Double Outlet Right Ventricle, Drug Dependence, Drug Dose Omission, Drug Effect Decreased, Drug Exposure Before Pregnancy, Drug Exposure During Pregnancy, Drug Exposure Via Breast Milk, Drug Ineffective, Drug Interaction, Drug Intolerance, Drug Level Increased, Drug Tolerance Decreased, Drug Toxicity, Drug Withdrawal Syndrome, Drug Withdrawal Syndrome Neonatal, Dyskinesia, Dyskinesia Neonatal, Dyspepsia, Dysphagia, Dyspnoea, Dyspraxia, Ear Infection, Ear Malformation, Ebstein's Anomaly, Eclampsia, Economic Problem, Ectopic Pregnancy, Ectopic Pregnancy Termination, Eczema, Electroencephalogram Abnormal, Emotional Disorder, Emotional Distress, Enamel Anomaly, Encephalitis, Encephalopathy Neonatal, Endometriosis, Epilepsy, Euphoric Mood, Exomphalos, Eye Disorder, Eye Movement Disorder, Eye Rolling, Eyelid Ptosis, Facial Palsy, Failed Induction of Labour, Failure To Thrive, Fall, Fallot's Tetralogy, False Labour, Fatigue, Fear, Feeding Disorder Neonatal, Feeding Disorder of Infancy or Early Childhood, Feeling Abnormal, Feeling Jittery, Fever Neonatal, Fine Motor Delay, Flatulence, Fluid Overload, Fluid Retention, Foetal Cardiac Disorder, Foetal Damage, Foetal Disorder, Foetal Distress Syndrome, Foetal Growth Retardation, Foetal Heart Rate, Foetal Heart Rate Abnormal, Foetal Heart Rate Decreased, Foetal Malformation, Food Allergy, Formication, Funisitis, Galactorrhoea, Gastric Disorder, Gastroenteritis Eosinophilic, Gastrointestinal Disorder, Gastrointestinal Malformation, Gastrooesophageal Cancer, Gastrooesophageal Reflux Disease, Genital Infection Bacterial, Gestational Diabetes, Glucose Tolerance Impaired, Glycosylated Haemoglobin Decreased, Glycosylated Haemoglobin Increased, Grand Mal Convulsion, Grip Strength Decreased, Growth Retardation, Grunting, Haemangioma, Haematochezia, Haematocrit Decreased, Haematoma, Haemorrhage, Haemorrhagic Disorder, Hallucination, Hallucination (Auditory), Head Deformity, Head Injury, Headache, Hearing Impaired, Heart Disease Congenital, Heart Rate Increased, Heart Valve Incompetence, Hellp Syndrome, Hepatic Congestion, Herpes Virus Infection, High Risk Pregnancy, Homicidal Ideation, Hormone Level Abnormal, Horseshoe Kidney, Hot Flush, Hunger, Hydronephrosis, Hyperemesis Gravidarum, Hyperphagia, Hyperreflexia, Hypersensitivity, Hypersomnia, Hypertelorism of Orbit, Hypertension, Hypertonia, Hypertonia Neonatal, Hypertrophy, Hyperventilation, Hypervigilance, Hypoaesthesia, Hypoaesthesia Facial, Hypocalcaemia, Hypoglycaemia, Hypoglycaemia Neonatal, Hypokinesia, Hypomagnesaemia, Hypopituitarism, Hypoplastic Left Heart Syndrome, Hypoplastic Right Heart Syndrome, Hypopnoea, Hypospadias, Hypothalamo-Pituitary Disorder, Hypothermia Neonatal, Hypothyroidism, Hypotonia, Hypotonia Neonatal, Hypoxia, Ill-Defined Disorder, Impaired Driving Ability, Imprisonment, Impulse-Control Disorder, Inappropriate Antidiuretic Hormone Secretion, Inappropriate Schedule of Drug Administration, Indirect Infection Transmission, Infantile Apnoeic Attack, Infertility, Inflammation, Influenza, Influenza Like Illness, Injury, Insomnia, Intentional Misuse, Intentional Self-Injury, Intercostal Retraction, Intra-Uterine Death, Irritability, Irritable Bowel Syndrome, Jaundice, Jaundice Neonatal, Joint Dislocation, Judgement Impaired, Kidney Enlargement, Laboratory Test Abnormal, Laboratory Test Interference, Labour Complication, Laceration, Large for Dates Baby, Laryngeal Stenosis, Laryngomalacia, Lethargy, Limb Deformity, Limb Malformation, Limb Operation, Limb Reduction Defect, Lipoatrophy, Liver Disorder, Lower Limb Deformity, Lung Disorder, Macrocephaly, Major Depression, Malaise, Malnutrition, Mania, Maternal Alcohol Use, Maternal Condition Affecting Foetus, Maternal Drugs Affecting Foetus, Maternal Use of Illicit Drugs, Medication Error, Memory Impairment, Menorrhagia, Menstrual Disorder, Menstruation Irregular, Mental Disorder, Mental Retardation Severity Unspecified, Mentally Late Developer, Metrorrhagia, Microcephaly, Migraine, Mild Mental Retardation, Mitral Valve Disease, Mitral Valve Hypoplasia, Mitral Valve Incompetence, Mitral Valve Prolapse, Mixed Receptive-Expressive Language Disorder, Mood Altered, Mood Swings, Movement Disorder, Multiple Allergies, Multiple Cardiac Defects, Multiple Congenital Abnormalities, Muscle Rigidity, Muscle Spasms, Muscle Twitching, Musculoskeletal Pain, Myoclonic Epilepsy, Myoclonus, Myotonia, Nasopharyngitis, Nausea, Neck Pain, Neonatal Apnoeic Attack, Neonatal Asphyxia, Neonatal Aspiration, Neonatal Complications of Substance Abuse, Neonatal Disorder, Neonatal Hypoxia, Neonatal Respiratory Acidosis, Neonatal Respiratory Distress Syndrome, Neonatal Respiratory Failure, Neonatal Tachycardia, Neonatal Tachypnoea, Nervous System Disorder, Nervousness, Neural Tube Defect, Neuralgia, Neurodevelopmental Disorder, Nightmare, Nystagmus, Oblique Presentation, Obsessive Thoughts, Obstetric Procedure Complication, Oligohydramnios, Oligomenorrhoea, Opisthotonus, Optic Neuritis, Oral Intake Reduced, Organ Failure, Osteoporosis, Otitis Media, Ovarian Cancer, Ovarian Cyst, Overdose, Overweight, Oxygen Saturation Decreased, Pain, Pain In Extremity, Palpitations, Pancreatitis Acute, Panic Attack, Paraesthesia, Paralysis, Paresis, Partial Seizures, Patent Ductus Arteriosus, Pericardial Effusion, Perinatal Brain Damage, Persistent Foetal Circulation, Personality Change, Personality Disorder, Phaeochromocytoma, Phobia, Photophobia, Placenta Praevia, Placental Disorder, Plasminogen Activator Inhibitor, Pleural Effusion, Pneumonia, Pneumonia Bacterial, Poisoning, Polydactyly, Polyhydramnios, Poor Sucking Reflex, Post Procedural Complication, Postmature Baby, Postpartum Depression, Postpartum Haemorrhage, Post-Traumatic Stress Disorder, Posture Abnormal, Pre-Eclampsia, Premature Baby, Premature Labour, Premature Rupture of Membranes, Premenstrual Syndrome, Presbyopia, Progesterone Decreased, Prolonged Labour, Psychomotor Hyperactivity, Psychomotor Skills Impaired, Psychotic Disorder, Pulmonary Artery Atresia, Pulmonary Hypertension, Pulmonary Hypoplasia, Pulmonary Oedema Neonatal, Pulmonary Valve Incompetence, Pulmonary Valve Stenosis, Pyloric Stenosis, Pyrexia, Rash Macular, Rash Neonatal, Reflexes Abnormal, Refusal of Treatment By Patient, Renal Aplasia, Renal Cyst, Renal Disorder, Renal Impairment, Renal Tubular Necrosis, Respiration Abnormal, Respiratory Depression, Respiratory Disorder, Respiratory Disorder Neonatal, Respiratory Distress, Respiratory Rate Increased, Respiratory Tract Infection, Restlessness, Retching, Retroplacental Haematoma, Rheumatoid Factor Increased, Rhinitis, Right Ventricular Hypertrophy, Road Traffic Accident, Rubella, Rubella Antibody Positive, Scar, Schizophrenia, Schizophrenia (Paranoid Type), Scoliosis, Seborrhoeic Dermatitis, Sedation, Sensation of Pressure, Sensory Integrative Dysfunction, Sensory Loss, Serotonin Syndrome, Serratia Infection, Shock, Single Functional Kidney, Sinusitis, Skin Burning Sensation, Skin Discolouration, Skin Lesion, Skin Striae, Skull Malformation, Sleep Apnoea Syndrome, Sleep Disorder, Sleep Study Abnormal, Small for Dates Baby, Snoring, Somnolence, Somnolence Neonatal, Speech Disorder, Speech Disorder Developmental, Spinal Deformity, Spine Malformation, Stillbirth, Strabismus, Strabismus Congenital, Stress, Sudden Death, Suicidal Ideation, Suicide Attempt, Supravalvular Aortic Stenosis, Supraventricular Tachycardia, Surgery, Swelling Face, Syncope, Syncope Vasovagal, Syndactyly, Synostosis, Tachycardia, Tachypnoea, Takayasu's Arteritis, Talipes, Tardive Dyskinesia, Tendonitis, Thalassaemia, Therapeutic Response Unexpected With Drug Substitution, Thermal Burn, Thyroid Disorder, Thyroiditis, Tinnitus, Tonic Clonic Movements, Tooth Disorder, Tooth Fracture, Tooth Injury, Torticollis, Transfusion Reaction, Transient Tachypnoea of the Newborn, Transmission of Drug Via Semen, Transposition of the Great Vessels, Treatment Noncompliance, Tremor, Tremor Neonatal, Tricuspid Valve Disease, Tricuspid Valve Incompetence, Trisomy 13, Trisomy 21, Ultrasound Antenatal Screen Abnormal, Umbilical Cord Abnormality, Umbilical Cord Around Neck, Underweight, Unevaluable Event, Univentricular Heart, Unresponsive To Pain Stimuli, Unresponsive To Stimuli, Unstable Foetal Lie, Unwanted Pregnancy, Upper Limb Deformity, Upper Respiratory Tract Infection, Urinary Tract Disorder, Urinary Tract Infection, Urine Ketone Body Present, Urine Output Decreased, Uterine Contractions Abnormal, Uterine Contractions During Pregnancy, Uterine Cyst, Uterine Haemorrhage, Uterine Leiomyoma, Vaginal Disorder, Vaginal Haemorrhage, Vaginal Infection, Vaginitis Bacterial, Vascular Anomaly, Vasoconstriction, Ventricular Hypoplasia, Ventricular Septal Defect, Ventriculo-Peritoneal Shunt, Vertical Infection Transmission, Vertigo, Viral Infection, Vision Blurred, Visual Disturbance, Vocal Cord Disorder, Vocal Cord Paralysis, Vocal Cord Paresis, Vomiting, Vomiting In Pregnancy, Vomiting Neonatal, Walking Disability, Weight Decrease Neonatal, Weight Decreased, Weight Gain Poor, Weight Increased, Wound Infection, Wrong Technique In Drug Usage Process

Definitions
Abortion Spontaneous	Miscarriage means loss of an embryo or fetus before the 20th week of pregnancy. Most miscarriages occur during the first 14 weeks of pregnancy. The medical term for miscarriage is spontaneous abortion.
Anal Atresia	The anus is either not present or it is in the wrong place.
Anencephaly	Congenital absence of most of the brain and spinal cord.
Ankyloglossia Congenital	A congenital anomaly in which the mucous membrane under the tongue is too short limiting the mobility of the tongue.
Atrial Septal Defect	An atrial septal defect (ASD), a congenital defect, occurs when there is an opening in the atrial septum, or dividing wall between the two upper chambers of the heart, known as the right and left atria. Normally, oxygen-poor (blue) blood returns to the right atrium from the body, travels to the right ventricle, then is pumped into the lungs where it receives oxygen. Oxygen-rich (red) blood returns to the left atrium from the lungs, passes into the left ventricle, then is pumped out to the body through the aorta. An atrial septal defect allows oxygen-rich (red) blood to pass from the left atrium through the opening in the septum, and then mix with oxygen-poor (blue) blood in the right atrium. This heart defect can cause lung problems if not repaired. When blood passes through the ASD from the left atrium to the right atrium, a larger volume of blood than normal must be handled by the right side of the heart, causing the right side to become overworked and enlarged. Extra blood then passes through the pulmonary artery into the lungs, causing higher pressure than normal in the blood vessels in the lungs, a condition known as pulmonary hypertension.
Congenital	A physical abnormality that is present at birth.
Digeorge's Syndrome	DiGeorge syndrome (also called congenital thymic hypoplasia, or third and fourth pharyngeal pouch syndrome) is a birth defect that is caused by an abnormal chromosome and affects the baby's immune system. The syndrome is marked by absence or underdevelopment of the thymus and parathyroid glands.
	DiGeorge syndrome is sometimes described as one of the "CATCH 22" disorders, so named because of their characteristics — cardiac defects, abnormal facial features, thymus underdevelopment, cleft palate, and hypocalcemia — caused by a deletion of several genes in chromosome 22. The specific facial features associated with DiGeorge syndrome include low-set ears, wide-set eyes, a small jaw, and a short groove in the upper lip.
Dyspnoea	Difficulty in breathing, often associated with lung or heart disease and resulting in shortness of breath. Also called air hunger.
Ebstein's Anomaly	Congenital downward displacement of the tricuspid valve into the right ventricle.
Ectopic Pregnancy	In an ectopic pregnancy, the fertilized egg implants in a location outside the uterus and tries to develop there. The word ectopic means "in an abnormal place or position." The most common site is the fallopian tube, the tube that normally carries eggs from the ovary to the uterus. However, ectopic pregnancy can also occur in the ovary, the abdomen, and the cervical canal (the opening from the uterus to the vaginal canal). The phrases tubal pregnancy, ovarian pregnancy, cervical pregnancy, and abdominal pregnancy refer to the specific area of an ectopic pregnancy.
Fallot's Tetralogy	A congenital malformation of the heart characterized by a defect in the ventricular septum, misplacement of the origin of the aorta, narrowing of the pulmonary artery, and enlargement of the right ventricle.
Hypoplastic Left Heart Syndrome	(Also known as HLHS), is a rare congenital heart defect in which the left side of the heart is severely underdeveloped. In babies with HLHS, the aorta and left ventricle are very small, and the aortic and mitral valves are either too small to allow sufficient blood flow or are atretic (closed) altogether. As blood returns from the lungs to the left atrium, it must pass through an atrial septal defect to the right side of the heart. In a healthy human, the left side of the heart receives oxygen-rich blood from the lungs and pumps it out to the rest of the body; with these structures underdeveloped, they cannot circulate blood to other organs, and the right ventricle must pump blood to both the lungs, as it would normally, and to the rest of the body, a situation which cannot be sustained for long. In cases of HLHS, the right side of the heart often must pump blood to the body through a patent ductus arteriosus. As the ductus arteriosus closes a few days after birth, blood flow is severely restricted and eventually cut off, leading to dangerously low circulation and eventually to shock.
Hypoplastic Right Heart Syndrome	(HRHS) refers to underdevelopment of the right sided structures of the heart. These defects cause inadequate blood flow to the lungs and thus, a blue or cyanotic infant. The major problem is pulmonary valve atresia (absence). This valve normally opens and closes to let blood flow to the pulmonary artery. Secondary problems include a very small (hypoplastic) right ventricle (lower chamber which normally pumps blood to the lungs); a small tricuspid valve (this valve allows blood to flow into the right ventricle) and a small (hypoplastic) pulmonary artery. Also, the blood flow into the coronary arteries may be abnormal causing damage to the heart muscle.
Neonatal Asphyxia	A condition in which an extreme decrease in the concentration of oxygen in the body accompanied by an increase in the concentration of carbon dioxide leads to loss of consciousness or death.
Neural Tube Defect	Any of various congenital defects of the brain and spinal cord, such as spina bifida, resulting from incomplete closing of the neural tube in an embryo.
Nystagmus	Rhythmic, oscillating motions of the eyes are called nystagmus. The to-and-fro motion is generally involuntary. Vertical nystagmus occurs much less frequently than horizontal nystagmus and is often, but not necessarily, a sign of serious brain damage. Nystagmus can be a normal physiological response or a result of a pathologic problem. ulation refers to a medical method of testing their connections to the brain, and therefore to the eyes. Cold or warm water flushed into the ear canal will generate motion signals from the inner ear. The eyes will respond to this signal with nystagmus if the pathways are intact.
Opisthotonus	A condition, caused by a tetanic spasm of the back muscles, in which the trunk is arched forward while the head and lower limbs are bent backward.
Persistent Foetal Circulation	The circulation of blood in the foetus is somewhat different from that of the baby after birth. This transition from foetal to neonatal circulation is one of the major physiologic changes after delivery. Before birth, the lungs are collapsed and the blood pressure in the lungs is quite high. This results in a very low blood flow through the lungs. After delivery, the lungs expand and the blood pressure in the lungs decreases.
	In some babies, although the lungs expand the blood vessels in the lungs remain constricted resulting in persistently high blood pressure in the lungs. This reduces the amount of blood that the infant can pump through the lungs. This decreased blood flow through the lungs after birth is called persistent foetal circulation because it is a persistence of the pattern of blood flow normally seen prior to birth during the foetal period.
Pulmonary Hypertension	From WebMD article:Babies whose mothers took antidepressant drugs in the second half of pregnancy are six times more likely to have a rare but dangerous lung ailment, a new study suggests.
	One study isn't proof. But it's strong evidence that taking SSRI antidepressants -- such as Prozac, Zoloft, and Paxil -- carries an extra risk during pregnancy.
	The risk is that the babies will have PPHN: persistent pulmonary hypertension of the newborn. Only one or two in a thousand babies get this, but it's very serious. It kills about one in 10 babies who get it. In moderately severe cases, half the survivors suffer hearing loss or brain damage.
Tardive Dyskinesia	Tardive dyskinesia is a mostly irreversible neurological disorder of involuntary movements caused by longterm use of antipsychotic or neuroleptic drugs.
	When these drugs are used long term, tardive dyskinesia (TD) can result. About 20 percent of people taking antipsychotic drugs for more then one year become affected by TD. The prevalence of TD tends to be highest among elderly patients and among women.
Transposition of the Great Vessels	In transposition of the great arteries (TGA), the aorta and pulmonary artery are reversed. The aorta receives the oxygen-poor blood from the right ventricle, but it's carried back to the body without receiving more oxygen. Likewise, the pulmonary artery receives the oxygen-rich blood from the left ventricle but carries it back to the lungs.
Trisomy 13	Patau syndrome, also called trisomy 13, is a congenital (present at birth) disorder associated with the presence of an extra copy of chromosome 13. The extra chromosome 13 causes numerous physical and mental abnormalities, especially heart defects.
Trisomy 21	Down syndrome is the most common cause of mental retardation and malformation in a newborn. It occurs because of the presence of an extra chromosome. The extra chromosome in Down syndrome is labeled number 21. For this reason, the existence of three such chromosomes is sometimes referred to as Trisomy 21.
Ventricular Septal Defect	A ventricular septal defect is a hole in the wall of the heart (septum) that separates the left lower chamber (left ventricle) from the right lower chamber (right ventricle). The hole allows blood to flow from the left ventricle to the right ventricle instead of entering the aorta for distribution throughout the body. Ventricular septal defect is one of a group of heart problems found in newborn babies that are collectively called congenital heart disease.